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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG1
All Species:
21.82
Human Site:
S489
Identified Species:
43.64
UniProt:
P19174
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P19174
NP_002651.2
1290
148532
S489
S
E
N
D
I
S
N
S
I
K
N
G
I
L
Y
Chimpanzee
Pan troglodytes
XP_514650
1630
185027
S829
S
E
N
D
I
S
N
S
I
K
N
G
I
L
Y
Rhesus Macaque
Macaca mulatta
XP_001087295
1291
148567
S489
S
E
N
D
I
S
N
S
I
K
N
G
I
L
Y
Dog
Lupus familis
XP_542998
1249
143812
P467
P
V
N
H
E
W
Y
P
H
Y
F
V
L
T
S
Cat
Felis silvestris
Mouse
Mus musculus
Q62077
1302
149650
S489
S
E
N
D
I
S
N
S
I
K
N
G
I
L
Y
Rat
Rattus norvegicus
P10686
1290
148530
S489
S
E
N
D
I
S
N
S
I
K
N
G
I
L
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q2VRL0
637
72514
Frog
Xenopus laevis
Q32NH8
758
87399
Q35
K
S
R
S
W
K
K
Q
R
Y
F
K
L
Q
E
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
K61
W
R
K
D
R
R
L
K
L
L
E
D
C
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13217
1095
124845
G372
L
D
C
W
N
G
K
G
E
D
E
E
P
I
V
Honey Bee
Apis mellifera
XP_624101
1134
132613
T411
Q
E
M
D
L
R
N
T
V
K
N
G
I
L
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
L217
P
R
M
V
A
E
E
L
L
T
R
Y
Q
Q
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79
99.5
93.2
N.A.
95.3
96.9
N.A.
N.A.
21.4
21.7
21.8
N.A.
21.4
45.1
N.A.
35.1
Protein Similarity:
100
79
99.7
94.5
N.A.
96.7
98.2
N.A.
N.A.
32.4
37.3
36.3
N.A.
40
62
N.A.
50
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
N.A.
0
0
6.6
N.A.
0
60
N.A.
0
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
N.A.
0
6.6
20
N.A.
13.3
80
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
0
9
0
59
0
0
0
0
0
9
0
9
0
0
0
% D
% Glu:
0
50
0
0
9
9
9
0
9
0
17
9
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
17
0
0
0
0
% F
% Gly:
0
0
0
0
0
9
0
9
0
0
0
50
0
0
9
% G
% His:
0
0
0
9
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
42
0
0
0
42
0
0
0
50
9
0
% I
% Lys:
9
0
9
0
0
9
17
9
0
50
0
9
0
0
0
% K
% Leu:
9
0
0
0
9
0
9
9
17
9
0
0
17
50
0
% L
% Met:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
50
0
9
0
50
0
0
0
50
0
0
0
0
% N
% Pro:
17
0
0
0
0
0
0
9
0
0
0
0
9
0
0
% P
% Gln:
9
0
0
0
0
0
0
9
0
0
0
0
9
17
0
% Q
% Arg:
0
17
9
0
9
17
0
0
9
0
9
0
0
0
0
% R
% Ser:
42
9
0
9
0
42
0
42
0
0
0
0
0
0
9
% S
% Thr:
0
0
0
0
0
0
0
9
0
9
0
0
0
9
9
% T
% Val:
0
9
0
9
0
0
0
0
9
0
0
9
0
9
9
% V
% Trp:
9
0
0
9
9
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
9
0
0
17
0
9
0
0
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _